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Showing 1 to 12 of 552 entries
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Rapid Reconstitution Packages (RRPs) implemented by integration of computational fluid dynamics (CFD) and 3D printed microfluidics.

Drug delivery and translational research

Chi A, Curi S, Clayton K, Luciano D, Klauber K, Alexander-Katz A, D'hers S, Elman NM.
PMID: 25787065
Drug Deliv Transl Res. 2014 Aug;4(4):320-33. doi: 10.1007/s13346-014-0198-7.

Rapid Reconstitution Packages (RRPs) are portable platforms that integrate microfluidics for rapid reconstitution of lyophilized drugs. Rapid reconstitution of lyophilized drugs using standard vials and syringes is an error-prone process. RRPs were designed using computational fluid dynamics (CFD) techniques...

Delivering regeneration.

Drug delivery and translational research

Shastri VP.
PMID: 25787171
Drug Deliv Transl Res. 2012 Oct;2(5):293-6. doi: 10.1007/s13346-012-0100-4.

No abstract available.

A reagent to facilitate protein recovery from cells and tissues.

Drug delivery and translational research

Hwang BH, Doshi N, Tsai KY, Mitragotri S.
PMID: 25787172
Drug Deliv Transl Res. 2012 Oct;2(5):297-304. doi: 10.1007/s13346-012-0071-5.

Collection of cytosolic proteins from cells and tissues is the first and essential step in many bioanalytical assays that play a key role in medical applications such as diagnostics, theranostics, and regenerative medicine. Dissolution of cell and tissue constituents...

Development of a UC781 releasing polyethylene vinyl acetate vaginal ring.

Drug delivery and translational research

McConville C, Major I, Friend DR, Clark MR, Malcolm RK.
PMID: 25787327
Drug Deliv Transl Res. 2012 Dec;2(6):489-97. doi: 10.1007/s13346-012-0101-3.

UC781 is potent, hydrophobic, non-nucleotide reverse transcriptase inhibitor (NNRTI) against the human immunodeficiency virus (HIV). UC781 is currently being investigated for use as a potential HIV microbicide. A study in rhesus macaques demonstrated that a 100-mg UC781-loaded silicone elastomer...

Drug delivery and translation.

Drug delivery and translational research

Kohane DS, Langer R.
PMID: 25787888
Drug Deliv Transl Res. 2011 Feb;1(1):4-6. doi: 10.1007/s13346-010-0002-2.

No abstract available.

A new approach for skin tumor treatment: from delivery system characterization to in vivo evaluation.

Drug delivery and translational research

Ainbinder D, Touitou E.
PMID: 25787889
Drug Deliv Transl Res. 2011 Feb;1(1):53-65. doi: 10.1007/s13346-010-0006-y.

Topical therapy for skin cancer is considered ineffective, due to insufficient penetration of the anticancer drug into the tumor located in the deep layers of the skin. The aim of this work was to investigate a new system, Tumorep...

Overcoming the stratum corneum barrier: a nano approach.

Drug delivery and translational research

Banerjee R.
PMID: 25788129
Drug Deliv Transl Res. 2013 Jun;3(3):205-8. doi: 10.1007/s13346-013-0149-8.

No abstract available.

Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet.

Drug delivery and translational research

Moes JJ, Stuurman FE, Hendrikx JJ, Marchetti S, Huitema AD, Beijnen JH, Schellens JH, Nuijen B.
PMID: 25788133
Drug Deliv Transl Res. 2013 Jun;3(3):243-51. doi: 10.1007/s13346-012-0127-6.

The ability to deliver the potent anti-cancer agent docetaxel via the oral route may enable the development of promising new treatment regimens with reduced toxicity, increased efficacy, and increased patient convenience. Recently, we were able to overcome the low...

Engineering a degradable polyurethane intravaginal ring for sustained delivery of dapivirine.

Drug delivery and translational research

Kaur M, Gupta KM, Poursaid AE, Karra P, Mahalingam A, Aliyar HA, Kiser PF.
PMID: 25788241
Drug Deliv Transl Res. 2011 Jun;1(3):223-37. doi: 10.1007/s13346-011-0027-1.

We describe the engineering of a degradable intravaginal ring (IVR) for the delivery of the potent HIV-1 reverse transcriptase inhibitor dapivirine. The degradable polymer used in fabricating the device incorporated poly(caprolactone) ester blocks in a poly(tetramethylene ether) glycol ABA...

Electrostatic droplets assisted synthesis of alginate microcapsules.

Drug delivery and translational research

Huang KS, Yang CH, Lin YS, Wang CY, Lu K, Chang YF, Wang YL.
PMID: 25788363
Drug Deliv Transl Res. 2011 Aug;1(4):289-98. doi: 10.1007/s13346-011-0020-8.

This paper demonstrates a proof-of-concept approach for encapsulating the insulin and Fe3O4 nanoparticles into size-controllable alginate microcapsules utilizing the electrostatic droplets (ESD) technique. We have established that the combination of ESD and external gelation is quite effective in producing...

Comparative oral bioavailability advantage from curcumin formulations.

Drug delivery and translational research

Munjal B, Pawar YB, Patel SB, Bansal AK.
PMID: 25788366
Drug Deliv Transl Res. 2011 Aug;1(4):322-31. doi: 10.1007/s13346-011-0033-3.

The aim of the present study was to study the oral bioavailability of seven different formulations of curcumin (CRM). CRM formulations viz. aqueous suspension, micronized suspension, nanosuspension, amorphous solid dispersion, hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex, combination with piperine, and spray-dried...

Curcumin implants for continuous systemic delivery: safety and biocompatibility.

Drug delivery and translational research

Bansal SS, Kausar H, Aqil F, Jeyabalan J, Vadhanam MV, Gupta RC, Ravoori S.
PMID: 25788367
Drug Deliv Transl Res. 2011 Aug;1(4):332-41. doi: 10.1007/s13346-011-0028-0.

Curcumin, an anti-oxidant, anti-inflammatory, and anti-neoplastic agent, exhibited limited oral efficacy due to its poor bioavailability. To overcome this limitation, polymeric implants for continuous systemic delivery of curcumin were developed and tested for their safety and biocompatibility. Two 2-cm...

Showing 1 to 12 of 552 entries